Scientist II, Computational Biology & AI

CRISPR Therapeutics seeks a computational biology scientist to advance gene-editing therapies. The company has evolved from a research stage to one with a diverse portfolio of product candidates across a broad range of disease areas.

Key Responsibilities

• Lead computational biology activities in drug development
• Generate and test hypotheses using analytical, statistical, and machine learning methods
• Characterize off-target gene editing for safety assessment
• Develop ML/AI tools to engineer and optimize CRISPR modalities
• Maintain reproducible computational pipelines for genomic analysis
• Author research reports supporting regulatory filings
• Present findings to leadership and stakeholders

Minimum Qualifications

• Ph.D. in computational biology, bioinformatics, genomics, machine learning, or related field
• 2+ years characterizing off-target editing or optimizing gene-editing
• Proficiency developing pipelines analyzing high-throughput DNA sequencing data
• Python proficiency (essential)
• Strong written/presentation skills and scientific rigor

Preferred Qualifications

• Linux/cloud environment expertise (AWS)
• Machine learning frameworks (PyTorch, TensorFlow, scikit-learn)
• Experience with protein prediction tools and biomolecular modeling
• Knowledge of sequencing platforms and NGS methods
• Regulatory filing documentation experience