Sr. Bioinformatics Scientist – cfDNA Technology Development

Personalis develops advanced genomics solutions for precision oncology. This role focuses on developing the NeXT Personal platform — an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay for detecting minimal residual disease and cancer recurrence.

Key Responsibilities

• Design and develop cell-free DNA platforms, particularly the NeXT Personal MRD liquid biopsy system
• Conduct cross-functional scientific projects evaluating product feasibility and clinical advantages
• Analyze large genomics datasets using novel methodologies
• Translate research findings into production-ready products
• Publish findings and present at industry conferences

Required Qualifications

• PhD in bioinformatics, genomics, or related discipline
• Extensive cancer genomics experience
• Proficiency with somatic mutation detection and filtering
• Hands-on cancer liquid biopsy analysis experience
• Programming competency in Python, R, or similar languages
• Demonstrated ability designing experimental approaches for complex projects
• Track record publishing and presenting scientific results

Salary: $155,000 - $190,000. Hybrid (Mon/Tue onsite).