Principal Statistical Programmer

Alnylam Pharmaceuticals seeks a Principal Statistical Programmer to provide expert-level hands-on programming support and technical leadership to develop, maintain, validate, and run SAS programs that access, visualize, analyze, and report clinical trial data.

Key Responsibilities

• Write programs that produce or validate tables, listings, figures and analysis datasets for clinical studies or complex integrated analyses for submission
• Develop and follow good programming practices, including documenting SAS and R code
• Plan and coordinate project work to ensure timely, quality delivery across multiple projects
• Create and validate global macros or systems that streamline repetitive operations
• Provide input into or lead general standardization efforts (CRFs, query checks, standard programs)
• Review DMP, eCRF specs, statistical analysis plans, and related documents
• Partner with or oversee CROs or programming vendors

Required Qualifications

• 8+ years pharmaceutical/biotech/CRO SAS programming experience
• Knowledge of clinical trials and experience reporting results for submission
• Experience constructing technical programming specifications and producing complex validated programs
• Strong experience with CDISC standards (SDTM, ADaM, Define xml)
• Excellent knowledge of SAS Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT
• Bachelor's degree required, Master's preferred
• R programming experience preferred

Salary: $151,300 - $204,700