Senior Scientist, Computational Genomics

We are seeking a first Computational Genomics hire, who will conduct crucial research that will form the basis of the company's scientific platform. As an early stage hire, you will operate with significant ownership, shaping analytical strategy from first principles, intersecting the fields of genomics, statistical genetics and statistical modeling. The role includes responsibility of the end-to-end delivery of computational research projects, including project design, implementation, interpretation and reporting results to senior leadership.

FL122 is a new venture pioneering genomic technologies at the intersection of human health and assisted reproduction, founded by Flagship Pioneering (creators of Moderna, Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics).

Key Responsibilities

• Deliver computational research projects with a high degree of autonomy, including project design, implementation, interpretation and reporting results to senior leadership
• Collaborate with cloud engineers to set up the required infrastructure to process and store genomics datasets
• Integrate multiple NGS data types into coherent analyses, going from raw input files to variant calls and higher level analyses
• Develop probabilistic and Bayesian models that rigorously incorporate priors, uncertainty, and missing data to inform decision-making
• Interact with external advisors, leveraging their inputs and building high-quality relationships

Requirements

• Ph.D. in biology, statistics, genetics, computational biology or a related quantitative discipline with 5+ years of relevant post-academic or industry experience with an excellent research track record
• Deep expertise in the analysis of genomics data derived from Illumina sequencing platforms (expertise with additional sequencing technologies is a plus)
• Experience processing next-generation sequencing data end-to-end, from raw reads through alignment, QC, and variant calling
• Experience integrating and jointly analyzing multi-modal sequencing datasets, including DNA and RNA
• Expertise in statistical genetics, computing polygenic risk scores using published methods and adapting or extending these methods for novel applications
• Expertise in building probabilistic statistical models that explicitly account for uncertainty, prior information, and incomplete observations
• Comfort operating in fast-moving, ambiguous startup environments with high ownership and accountability

Salary: $146,000 - $209,000. Also offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.