Sr. Bioinformatics Scientist

Senior Bioinformatics Scientist at Veracyte. South San Francisco, CA.

Lead bioinformatics design, development, and validation for regulated cancer diagnostic products using next-generation sequencing technology.

Key Responsibilities

• Lead bioinformatics design, development, and validation for new and existing products
• Drive study design and analysis for assay development
• Develop statistical and machine learning techniques for assay performance evaluation
• Create scalable, production-grade NGS workflows using AWS and containerized environments
• Maintain regulatory compliance (CAP/CLIA, FDA, IVDR) with thorough testing and documentation
• Contribute to regulatory submissions and audits
• Mentor junior bioinformatics team members

Required Qualifications

• PhD/MS in bioinformatics, computational biology, biostatistics, or computer science
• 6-7+ years in bioinformatics analysis, algorithm development, and pipeline implementation
• Deep understanding of NGS technologies and library preparation (WGS, enrichment, RNA-Seq, methylation)
• Proficiency in quantitative transcriptomics (differential expression, classifier development, RNA signatures)
• Machine learning expertise and algorithm benchmarking
• AWS deployment experience (EC2, S3, Step Functions, Batch, Lambda)
• Strong Python skills with testing frameworks and SDLC best practices