ML Platform / MLOps Engineer

Profluent
Location
Emeryville, California, United States; Hybrid (2-3 days on-site)
Job Type
Full-time
Reposted
June 3, 2026
Originally posted Apr 24, 2026
Views
5

Job Description

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.

As we continue to push the boundaries of what is possible, we’re seeking anML Platform / MLOps Engineeron the machine learning team to build and operate the infrastructure that powers our machine learning systems. You will work closely with machine learning scientists, protein design scientists, and engineers to enable reliable, scalable platforms for training, evaluating, and deploying large-scale generative biology models.

As an early member of the company, you’ll have significant ownership over the systems and tools that enable our research team to move quickly from experiments to production models.

What You'll Work On

  • Infrastructure supporting large-scale generative models for proteins
  • Systems that process massive biological datasets
  • Experimentation platforms that enable rapid iteration by ML researchers
  • Production services powered by machine learning models

Responsibilities

  • Develop infrastructure that enables researchers to run large-scale ML training and inference workloads reliably and efficiently on GPU clusters
  • Implement and maintain security best practices across our ML infrastructure, including access control, secrets management, and least-privilege policies
  • Monitor and optimize infrastructure performance, reliability, and cost
  • Evaluate different open source infrastructure solutions and cloud providers
  • Build and maintain machine learning pipelines to support model inference workloads
  • Implement CI/CD pipelines for machine learning models and services
  • Develop tooling that helps researchers move quickly from experiments to production models

Qualifications

  • BS in Computer Science or a related field
  • 3+ years of experience building or operating production ML systems
  • Experience with MLOps, ML infrastructure, or ML platform engineering
  • Strong experience with cloud infrastructure (GCP preferred)
  • Experience working with containerized workloads and orchestration systems (Kubernetes, Docker)
  • Experience building data or ML pipelines
  • Familiarity with CI/CD and infrastructure-as-code practices

Preferences (but not required)

  • Experienced with the challenges of working with large scale ML models
  • Experience with transitioning research ideas into production
  • Familiarity with ML frameworks such as PyTorch, MLFlow
  • Interested in the intersection between biology and AI

What We Offer

  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship.Sponsorship will not be provided now or at any time in the future for this position.

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.

As we continue to push the boundaries of what is possible, we’re seeking anML Platform / MLOps Engineeron the machine learning team to build and operate the infrastructure that powers our machine learning systems. You will work closely with machine learning scientists, protein design scientists, and engineers to enable reliable, scalable platforms for training, evaluating, and deploying large-scale generative biology models.

As an early member of the company, you’ll have significant ownership over the systems and tools that enable our research team to move quickly from experiments to production models.

What You'll Work On

  • Infrastructure supporting large-scale generative models for proteins
  • Systems that process massive biological datasets
  • Experimentation platforms that enable rapid iteration by ML researchers
  • Production services powered by machine learning models

Responsibilities

  • Develop infrastructure that enables researchers to run large-scale ML training and inference workloads reliably and efficiently on GPU clusters
  • Implement and maintain security best practices across our ML infrastructure, including access control, secrets management, and least-privilege policies
  • Monitor and optimize infrastructure performance, reliability, and cost
  • Evaluate different open source infrastructure solutions and cloud providers
  • Build and maintain machine learning pipelines to support model inference workloads
  • Implement CI/CD pipelines for machine learning models and services
  • Develop tooling that helps researchers move quickly from experiments to production models

Qualifications

  • BS in Computer Science or a related field
  • 3+ years of experience building or operating production ML systems
  • Experience with MLOps, ML infrastructure, or ML platform engineering
  • Strong experience with cloud infrastructure (GCP preferred)
  • Experience working with containerized workloads and orchestration systems (Kubernetes, Docker)
  • Experience building data or ML pipelines
  • Familiarity with CI/CD and infrastructure-as-code practices

Preferences (but not required)

  • Experienced with the challenges of working with large scale ML models
  • Experience with transitioning research ideas into production
  • Familiarity with ML frameworks such as PyTorch, MLFlow
  • Interested in the intersection between biology and AI

What We Offer

  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • 401(k) with a strong employer match
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship.Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

Hiring Salary Range

$180,000—$250,000 USD

Frequently Asked Questions

Where is the job located, and is it remote?
This position is located in Emeryville, California, United States, and is a hybrid role requiring 2-3 days on-site.
What is the salary range for this position?
The hiring salary range for this role is $180,000 - $250,000 USD.
What are the key responsibilities for this role?
You will develop infrastructure for large-scale ML training, maintain security best practices, monitor infrastructure performance, evaluate open source solutions, build ML pipelines, implement CI/CD, and develop tooling for researchers.
What qualifications are required for this role?
A BS in Computer Science or related field, 3+ years of experience building or operating production ML systems, and experience with MLOps, cloud infrastructure (GCP preferred), containerization (Kubernetes, Docker), data or ML pipelines, and CI/CD.
Does Profluent offer visa sponsorship for this position?
No, Profluent will not provide visa sponsorship now or in the future for this position.
What benefits does Profluent offer?
Profluent offers a competitive compensation package with equity, a 401(k) with employer match, health/dental/vision insurance, generous PTO, and professional development opportunities.

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Job Information

Source: greenhouse
AI Relevance: 60/100 (Relevant)
Remote Type: hybrid
Allowed Locations: Emeryville, California, United States; Hybrid (2-3 days on-site)
Skills & Tags:
Machine Learning

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