Principal Scientist, Medicinal Chemistry

Genentech
Genentech logo
Location
South San Francisco
Job Type
Full-time
Posted
May 30, 2026
Views
92
Salary Range
$144k - $269k USD

Job Description

We advance science so that we all have more time with the people we love.

We have an exciting opportunity for a talented chemist to join our Small-Molecule Drug Discovery Chemistry Department at Genentech in South San Francisco, CA.

The Opportunity

The successful candidate will be responsible for designing and synthesizing analogs for molecular targets by applying innovative structure- and computation-driven and property-based design principles in a multi-disciplinary, team-based culture. In addition to close collaboration with other chemists, the candidate will engage with various functions such as Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety and disease area Biology.

Who You Are

  • A PhD with 0-6 years of post-PhD experience, or equivalent and relevant experience in chemical research.

  • Expertise in modern synthetic organic chemistry is required as demonstrated by a track record of at least one first authored publication(s).

  • Ability to conduct multi-step syntheses and retrosynthetic analysis of complex molecules.

Preferred

  • You will demonstrate extensive experience and record of accomplishment in one or more of the following areas: medicinal chemistry, methodology/catalysis, total synthesis, chemical biology and physical organic chemistry.

  • You will convey strong verbal and written communication skills and an ability to work collaboratively in teams.

  • Candidates with significant industry experience should be prepared to fully disclose details of accomplishments.

Applicants are requested to submit a Research Summary in addition to their CV.

Relocation benefits are available for this job posting.

The expected salary range for this position based on the primary location of California is $144,000 and $269,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

#LI-KC2

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this formAccommodations for Applicants.

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Frequently Asked Questions

Where is this job located?
This position is located in South San Francisco, California.
What are the key responsibilities for this role?
You will design and synthesize analogs for molecular targets, applying innovative design principles in a team-based culture. This includes collaborating with chemists and other functions like Drug Metabolism and Pharmacokinetics.
What qualifications are required for this role?
A PhD with 0-6 years of post-PhD experience (or equivalent) and expertise in synthetic organic chemistry, demonstrated by at least one first-authored publication. Ability to conduct multi-step syntheses and retrosynthetic analysis of complex molecules is also required.
What is the salary range for this position?
The expected salary range for this position in California is $144,000 to $269,100. Actual pay will be based on experience, qualifications, and location.
Are relocation benefits provided?
Yes, relocation benefits are available for this job.
What benefits are offered?
This position qualifies for benefits detailed at the provided link. A discretionary annual bonus may also be available based on individual and company performance.
What should I submit with my application?
Please submit a Research Summary in addition to your CV.

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Research the company before you apply.

  • 37 open roles
  • Verified H-1B salary data
  • Clinical-trial hiring momentum
  • Culture, benefits & locations
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Job Information

Source: workday
AI Relevance: 80/100 (Highly relevant)
Remote Type: onsite
Allowed Locations: South San Francisco
Skills & Tags:
genentech pharma

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