Senior Computational Biologist

Gordian Biotechnology seeks a Senior Computational Biologist to analyze single-cell transcriptomic perturbation screens and translate findings into biological conclusions for cardio-renal-metabolic disease therapeutics. The role involves developing analytical approaches, partnering with disease experts, integrating public genomics data, and establishing validation criteria to improve screening efficiency.

Key Responsibilities

• Analyze single-cell transcriptomic perturbation screening data
• Translate computational findings into biological conclusions for cardio-renal-metabolic disease
• Develop novel analytical approaches for perturbation screen analysis
• Partner with disease biology experts and experimental teams
• Integrate public genomics datasets to contextualize internal findings
• Establish validation criteria to improve screening efficiency

Required Qualifications

• PhD in Bioinformatics, Computational Biology, or related quantitative field
• 2+ years hands-on single-cell transcriptomic analysis experience
• At least one peer-reviewed publication or preprint with major contribution
• Proficiency in Python and R (Scanpy, Seurat)
• Experience with NGS workflows and high-performance computing (AWS, GCP)
• Strong statistical foundations and cross-functional communication skills

Valued Additional Skills

• Pooled perturbation/CRISPR screening experience
• Cardio-renal-metabolic biology background
• Large-scale public genomics data integration
• Preclinical validation model experience

Benefits include competitive salary, equity, full health/dental/vision/life insurance, 401k with match, paid onsite lunches (3x/week), onsite gym, unlimited vacation. South San Francisco, CA (hybrid).