Senior Principal Scientist I, Lab Head, Protein Engineering

Job title:Senior Principal Scientist I, Lab Head, Protein Engineering

• Location:Cambridge, MA

About the job

AsSenior Principal Scientist I, Lab Head, Protein Engineeringwithin ourR&D team, you will lead a multidisciplinary team within the Protein Engineering group at our Cambridge Crossing research site. In this role, you will collaborate closely with two complementary labs within the Protein Engineering group — Structural Biology & Protein Design and Developability & Analytics — to advance our protein engineering capabilities and drive innovation across the group.

This leadership position offers a unique opportunity to shape the future of biologics engineering by combining deep experimental expertise with computational protein design, AI-enabled engineering, automation, and data-driven discovery. You will lead innovative antibody engineering strategies across diverse therapeutic modalities while working closely with other global LMR sites and LMR Digital Biologics. As Lab Head, you will help drive the evolution of Sanofi's next-generation antibody engineering platforms by integrating structure-guided design, high-throughput experimental technologies, protein language models, computational modeling, and AI/ML-enabled engineering approaches into biologics discovery workflows. You will represent Protein Engineering on multidisciplinary project teams, provide scientific leadership from early discovery through lead optimization, and contribute to the strategic direction of global engineering capabilities across LMR.

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities

• Lead protein engineering strategies for the design and optimization of multispecific antibodies, Fc-engineered molecules, fusion proteins, and other next-generation biologic modalities using experimental and computational approaches.

• Design and execute antibody engineering campaigns including affinity maturation, molecular format engineering, developability optimization, and functional optimization through structure-guided, computational, and data-driven design.

• Develop and continuously improve protein engineering platforms utilizing yeast and/or phage display, high-throughput screening, saturation mutagenesis, in silico-guided library design, linear expression cassette (LEC) workflows and automation.

• Partner closely with LMR Digital Biologics and global Protein Engineering community to integrate computational modeling, protein language models, machine learning, generative AI approaches, and experimental validation into engineering strategies.

• Identify and implement innovative technologies that enhance engineering efficiency, data quality, and scientific decision-making across biologics discovery.

• Serve as the Protein Engineering representative on cross-functional project teams, collaborating with Therapeutic Areas and partner functions to define engineering strategies, coordinate project activities, and support milestone progression.

• Lead, mentor, and develop a high-performing team of 5 scientists (scientists to principal scientists) while fostering scientific excellence, innovation, collaboration, and continuous learning.

• Contribute to global LMR Antibody Engineering initiatives by establishing best practices, sharing technologies across research sites, developing platform capabilities, and driving scientific innovation throughout the organization.

• Communicate scientific discoveries through presentations, publications, patents, and external scientific engagement.

About you

• Ph.D. in Biochemistry, Molecular Biology, Biomedical Sciences, Bioengineering, Structural Biology, or a related discipline

• 9+ years of industry experience in biotechnology or pharmaceutical research.

• Demonstrated scientific leadership in antibody and protein engineering, including multispecific antibodies, Fc engineering, affinity maturation, and molecular optimization.

• Extensive experience with yeast and/or phage display technologies, antibody library design and construction, high-throughput screening, protein expression, purification, protein-protein interaction measurement and biophysical characterization.

• Strong understanding of protein structure-function relationships and engineering strategies to optimize affinity, specificity, biological activity, developability, and manufacturability.

• Experience leveraging Genedata Biologics or comparable digital platforms to support biologics discovery and engineering workflows.

• Demonstrated ability to integrate computational design and AI-enabled approaches into protein engineering programs through collaboration with computational scientists and digital biology teams.

• Proven experience leading multidisciplinary project teams and managing a team of scientists in a collaborative research environment.

• Strong scientific communication skills with a demonstrated record of publications, patents, scientific presentations, and innovation.

Preferred Qualifications

• Experience applying modern computational protein design approaches, including protein language models, ML-guided engineering, generative AI, and structure prediction tools to biologics discovery.

• Experience with computational modeling software such as MOE, Rosetta, AlphaFold, PyMOL, or related platforms.

• Experience developing automated and high-throughput protein engineering workflows.

• Experience in additional protein engineering disciplines including glycoengineering, chemical conjugation, protein conjugates, or emerging biologic modalities.

Why Choose Us

• Bring the miracles of science to life alongside a supportive, futurefocused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.

• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

• Help improve the lives of millions of people globally by making drug development quicker and more effective.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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Pursueprogress, discoverextraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch ourALL IN videoand check out our Diversity Equity and Inclusion actions atsanofi.com!

US and Puerto Rico Residents Only

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

North America Applicants Only

The salary range for this position is:

All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through theLINK.