Principal Bioinformatician

We are looking for a skilled and motivated Computational Biologist to join the Bioinformatics and Biostatistics (BBS) Team within the CRUK National Biomarker Centre (NBC). With national and international colleagues, the primary objective of this role is to innovate and apply multi-omics approaches to build a ‘molecular atlas’ of rare cancers. The secondary objective is to discover candidate biomarkers of treatment response or resistance and disease progression in rare cancers harbouring targeted oncogenic alterations from patients enrolled in the pioneering DETERMINE Trial .

The role involves analysis of multimodal data sets generated within the NBC and by the DETERMINE TRANSLATIONAL, an international, multi-site Cancer Research UK funded programme. This includes genomic, epigenomic, transcriptomic, immunological and imaging data from patient blood and tissue samples. You will apply statistical and machine learning approaches, including modern AI methodologies where appropriate, to identify molecular signatures associated with treatment response, resistance and disease progression. You will have access to state-of-the-art facilities at the NBC and the CRUK Manchester Institute, including their high-performance computing resources.

Job reference: NBC/26/34

Salary: £37,638 - £52,000 per annum, dependent upon experience

Applications closing date: 04/10/2026 (18:00 UK time)

To apply, complete the online application via the University of Manchester recruitment portal.

Informal enquiries: seva.makeev@cruk.manchester.ac.uk