Senior Scientist, Target Discovery & Biology - Functional Genomics

Amgen
Amgen logo
Location
South San Francisco, California
Job Type
Full-time
Posted
September 20, 2026
Views
11

Job Description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist, Target Discovery & Biology - Functional Genomics

What you will do

Lets do this. Lets change the world. In this vital role you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease-relevant systems, including complex biological models from in vitro to in vivo, to advance target discovery and validation across Amgens therapeutic areas.

Key Responsibilities

Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questionsLead, support and execute projects from inception through target identification, validation and mechanism-of-action studiesFoster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgens pipeline

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

Basic Qualifications

Doctorate degree PhD

OR

PharmD OR

MD [and relevant post-doc scientific experience in Target Discovery & Biology]

OR

Masters degree and 3 years of relevant scientific experience in Target Discovery & Biology

OR

Bachelors degree and 5 years of relevant scientific experience in Target Discovery & Biology

Preferred Qualifications

Strong experience in molecular biology and cell engineering. Experience in complex and co-culture in vitro models is a major plusExperience in executing large scale, complex, and/or in vivo genetic screens (particularly CRISPR-based) and follow up validation studies. Track record of pushing the envelope on scale and technical feasibility is highly desirableFamiliarity with data-driven discovery approaches, including integration of genetic or multi-omics insightsExcellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environmentAdditional experience relevant to applying functional genomics approaches to new target discovery across diverse indicationsTrack record of scientific productivity and innovation as demonstrated through career experiences, project outcomes and/or publicationsTrack record of taking on new areas of research and biology with successful outcomes

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist, Target Discovery & Biology - Functional Genomics

What you will do

Lets do this. Lets change the world. In this vital role you will join the Target Discovery & Biology team in South San Francisco. This role will leverage functional genomics in disease-relevant systems, including complex biological models from in vitro to in vivo, to advance target discovery and validation across Amgens therapeutic areas.

Key Responsibilities

Leverage functional genomics approaches across therapeutic areas to discover novel targets and address key biological questionsLead, support and execute projects from inception through target identification, validation and mechanism-of-action studiesFoster a collaborative, creative, and scientifically rigorous team culture committed to delivering impact across Amgens pipeline

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a researcher with these qualifications.

Basic Qualifications

Doctorate degree PhD

OR

PharmD OR

MD [and relevant post-doc scientific experience in Target Discovery & Biology]

OR

Masters degree and 3 years of relevant scientific experience in Target Discovery & Biology

OR

Bachelors degree and 5 years of relevant scientific experience in Target Discovery & Biology

Preferred Qualifications

Strong experience in molecular biology and cell engineering. Experience in complex and co-culture in vitro models is a major plusExperience in executing large scale, complex, and/or in vivo genetic screens (particularly CRISPR-based) and follow up validation studies. Track record of pushing the envelope on scale and technical feasibility is highly desirableFamiliarity with data-driven discovery approaches, including integration of genetic or multi-omics insightsExcellent organizational and communication skills, with the ability to drive cross-site collaboration in a matrixed research environmentAdditional experience relevant to applying functional genomics approaches to new target discovery across diverse indicationsTrack record of scientific productivity and innovation as demonstrated through career experiences, project outcomes and/or publicationsTrack record of taking on new areas of research and biology with successful outcomes

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

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Frequently Asked Questions

Where is the job located, and is it remote/hybrid/on-site?
The position is located in South San Francisco, California. Amgen offers flexible work models where possible, and candidates should refer to the Work Location Type in the job posting to see if it applies to this role.
What are the required qualifications for this role?
You must have a PhD, PharmD, or MD with relevant post-doc scientific experience in Target Discovery & Biology. Alternatively, you can have a Master's degree with 3 years of relevant scientific experience, or a Bachelor's degree with 5 years of relevant scientific experience in Target Discovery & Biology.
What are the key responsibilities of the Senior Scientist?
You will leverage functional genomics to discover novel targets and address biological questions. You will lead, support, and execute projects from inception through target identification, validation, and mechanism-of-action studies, while fostering a collaborative, creative, and scientifically rigorous team culture.
What benefits does Amgen offer?
Amgen offers a Total Rewards Plan including health, dental, and vision coverage, a Retirement and Savings Plan with company contributions, life and disability insurance, flexible spending accounts, a discretionary annual bonus program, stock-based long-term incentives, and time-off plans.
Is visa sponsorship available for this position?
Sponsorship for this role is not guaranteed.
What is the application deadline and process?
There is no set application deadline; Amgen will accept applications until a sufficient number are received or a candidate is selected. When applying, you may redact or remove age-identifying information (such as dates of birth or graduation) from your materials without penalty.

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Job Information

Source: biospace
AI Relevance: 80/100 (Highly relevant)
Remote Type: onsite
Allowed Locations: South San Francisco, California
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