Principal Scientist – Computational Biology & Translational AI (Oncology Precision Medicine)

Amgen seeks a Principal Scientist in Computational Biology & Translational AI focused on developing AI-enabled analytical systems connecting preclinical and clinical data across oncology programs.

Key Responsibilities

• Lead pan-asset forward and reverse translational analyses integrating multiple data types to generate mechanistic insights
• Design generative and agentic AI systems for hypothesis generation and evidence synthesis
• Develop multi-agent workflows integrating omics, imaging, pathology, and clinical data
• Build reproducible translational analysis pipelines with AI integration
• Partner with biology, pathology, and clinical teams to contextualize translational signals
• Communicate findings to clinical and scientific stakeholders

Minimum Qualifications (one of)

• PhD/PharmD/MD + 2 years computational biology experience
• Master's + 5 years experience
• Bachelor's + 7 years experience

Preferred Qualifications

• PhD in bioinformatics, statistics, computer science, or related field with biology foundation
• Demonstrated expertise in translational science linking molecular mechanisms to clinical outcomes
• Hands-on experience with generative or agentic AI systems
• Multi-modal data integration experience
• Strong programming in R and/or Python
• Knowledge of clinical biomarker platforms

Salary: $167,413 - $226,501 annually