Computational Chemist, Senior Scientist II / Principal Scientist I

Schrödinger
Location
New York, NY
Job Type
Full-time
Reposted
June 14, 2026
Originally posted Mar 30, 2026
Views
313
Salary Range
$120k - $165k USD

Job Description

We're seeking a Computational Chemist to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.

Our drug discovery group of over 60 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large-scale computer infrastructure. Four of the programs we've worked on in the past seven years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA.

Who will love this job

  • A structure-based drug designer who has experience in two of the following molecular modeling areas: virtual ligand screening, computationally-driven lead optimization, machine learning, molecular dynamics, quantum mechanics, cheminformatics, ADMET/QSPR
  • An excellent communicator who's been exposed to one or more other disciplines of relevance to drug discovery, such as synthetic organic chemistry, pharmacology, toxicology, formulation, biochemistry, physical chemistry, or analytical chemistry
  • A team player who enjoys working in interdisciplinary environments and has some background in programming/scripting and/or chemically-aware databases
  • A pharma/biotech veteran

What you'll do

  • Support active drug discovery projects as a computational chemist/modeler
  • Work closely with internal software development teams to improve our drug discovery technologies

What you should have

  • PhD in computational chemistry, organic chemistry, or physical chemistry, preferably with postdoctoral experience or 1 to 5 years industry experience

Pay and perks

Competitive salary, equity-based compensation, and a wide range of benefits including healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. Regular catered meals in the office, a relaxed-but-engaged culture, and over a month of paid vacation time. Schrödinger has been included in Newsweek's list of America's 100 Most Loved Workplaces.

Estimated base salary range: $120,000 – $165,000. Actual compensation package is dependent on a number of factors, including experience, education, degrees held, market data, and business needs.

Frequently Asked Questions

Where is the job located, and is it remote/hybrid/on-site?
The job is located in New York, NY. The posting does not specify a remote or hybrid work-mode policy, but it mentions a flexible work schedule and regular catered meals in the office.
What are the required qualifications and experience level for this role?
You should have a PhD in computational chemistry, organic chemistry, or physical chemistry. Postdoctoral experience or 1 to 5 years of industry experience is preferred.
What are the key responsibilities of the position?
You will support active drug discovery projects as a computational chemist/modeler and work closely with internal software development teams to improve Schrödinger's drug discovery technologies.
What is the salary range for this role?
The estimated base salary range is $120,000 – $165,000. The actual compensation package depends on factors such as experience, education, degrees held, market data, and business needs.
What benefits and perks does the company offer?
Benefits include equity-based compensation, healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, a parental leave program, regular catered in-office meals, and over a month of paid vacation time.

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Job Information

Source: manual
AI Relevance: 85/100 (Highly relevant)
Remote Type: onsite
Experience: Senior
Allowed Locations: Worldwide
Skills & Tags:
computational chemistry drug discovery molecular modeling virtual screening molecular dynamics quantum mechanics cheminformatics ADMET QSPR structure-based drug design

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