AI Scientist, BioMedical AI

Xaira is an AI-driven biotech developing generative AI models to design protein and antibody therapeutics, plus foundation models for biology and disease to enable better target elucidation and patient stratification. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

We are looking for an AI Scientist to join our team at the intersection of machine learning and single-cell biology. This role will focus on developing and applying foundation models to large-scale perturb-seq and single-cell datasets to uncover new biological mechanisms and therapeutic opportunities. You will help design scalable ML architectures that can extract insight from high-dimensional perturbation data and integrate across multi-omic modalities.

Key Responsibilities

• Design, train, and refine foundation models tailored to perturb-seq and other single-cell datasets. Build pipelines for preprocessing, normalization, and integration of large-scale single-cell and perturbation data.
• Apply ML/AI approaches to model cellular responses to perturbations and identify causal biological insights.
• Collaborate with experimental biologists to align computational methods with experimental design and discovery goals.
• Develop multimodal integration approaches across transcriptomic, epigenomic, and proteomic single-cell readouts.
• Publish methods and results in top scientific journals and present at conferences.

Qualifications

• PhD or equivalent in Computational Biology, Computer Science, Bioinformatics, or related discipline.
• Strong expertise in single-cell data analysis, particularly perturb-seq.
• Hands-on experience with foundation models or large-scale self-supervised learning (e.g., transformers, variational autoencoders).
• Strong coding skills in Python, ML frameworks (PyTorch/TensorFlow), and single-cell analysis tools (Scanpy, Seurat).
• Experience in developing scalable ML methods for large biological datasets.

Preferred

• Background in causal inference, generative models, or representation learning for biological systems.
• Familiarity with multi-omics integration and cross-modal foundation models.
• Track record of impactful publications in computational biology, machine learning, or related fields.

Compensation: The base pay range for this position is expected to be $150,000 - $240,000 annually; the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience. The package also includes bonus and equity.