Computational Chemist

Schrödinger
Location
New York; Cambridge, MA; San Diego; Portland
Job Type
Full-time
Posted
October 27, 2026
Salary Range
$100k - $180k USD

Job Description

We’re seeking aComputational Chemistto join us in our mission to transform the discovery of therapeutics.

As a member of the Schrödinger Therapeutics Group (STG), you’ll join a team  of over 60 scientists that includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large-scale computer infrastructure.

Who will love this job:

  • A structure-based drug designer who may have postdoctoral or pharma/biotech experience
  • An excellent communicator who’s been exposed to one or more other disciplines of relevance to drug discovery, such as synthetic organic chemistry, pharmacology, toxicology, formulation, biochemistry, physical chemistry, or analytical chemistry
  • A computational chemist who’s familiar with coding/scripting languages and/or chemically-aware databases
  • A team player who enjoys working in interdisciplinary environments

What you’ll do:

  • Provide computational chemistry/modeling support to active drug discovery projects while assisting and developing appropriate modeling approaches to help drive drug discovery projects and methods development
  • Troubleshoot computational problems
  • Share knowledge with the greater Schrödinger Therapeutic Group (STG)
  • Work closely with the internal software development teams to improve Schrödinger’s drug discovery technologies

What you should have:

  • Ph.D. in computational chemistry, or related field
  • Robust scientific training in molecular modeling, statistical mechanics, and/or quantum mechanics, as well as one or more of the following areas: computationally-driven lead optimization, molecular dynamics, free-energy methods, machine learning, virtual ligand screening, cheminformatics, ADMET modeling

Pay and perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have a company culture that is relaxed, but engaged, and over a month of paid vacation time.  Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces.

Estimated base salary range: $100,000 - $180,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

Frequently Asked Questions

Where is this job located, and what is the work setting?
The job is located in New York, NY; Cambridge, MA; San Diego, CA; and Portland, OR. The posting notes that Schrödinger offers a flexible work schedule, though specific remote, hybrid, or on-site policies are not explicitly detailed.
What qualifications and experience are required for this role?
Candidates must have a Ph.D. in computational chemistry or a related field. You should have robust scientific training in molecular modeling, statistical mechanics, or quantum mechanics, alongside experience in areas like lead optimization, molecular dynamics, machine learning, cheminformatics, or ADMET modeling. Postdoctoral or pharma/biotech experience and familiarity with coding languages are also valued.
What are the key responsibilities of a Computational Chemist here?
You will provide computational chemistry and modeling support to active drug discovery projects, troubleshoot computational problems, share knowledge with the Therapeutics Group, and collaborate closely with internal software development teams to enhance Schrödinger’s drug discovery technologies.
What is the salary range for this position?
The estimated base salary range is $100,000 to $180,000. Actual compensation depends on factors such as experience, education, degrees held, market data, and business needs.
What benefits and perks does Schrödinger offer?
Benefits include equity-based compensation, healthcare (with dental and vision), a 401(k), parental leave, over a month of paid vacation time, pre-tax commuter benefits, a flexible work schedule, and company-wide events planned by the Office Management team.
What team will I be joining?
You will join the Schrödinger Therapeutics Group (STG), an interdisciplinary team of over 60 scientists—including designers, computational chemists, medicinal chemists, and biologists—supported by more than 100 software developers and engineers.

Ready to Apply?

Apply for this Position

You'll be redirected to the company's application page

Share this job:
WhatsApp LinkedIn X Email

Job Information

Source: greenhouse
AI Relevance: 90/100 (Highly relevant)
Remote Type: onsite
Skills & Tags:
STG

Get Similar Jobs by Email

Weekly digest of Schrödinger and similar companies. Free.

Related Jobs

Apply for this Position

Get weekly job alerts