Advisor / Sr. Advisor, Mass Spectrometry-based Biomarker Discovery - Neuroscience

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

About Lilly

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 47,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Overview

Lilly’s Neuroscience Research team is dedicated to the advancement of innovative therapies and diagnostics for the treatment of neurological disorders. We are currently seeking an individual with expertise and knowledge in biomarker discovery, with a demonstrated “hands-on“ track record in mass spectrometry-based methodologies. The successful candidate will play an important role in the development and discovery of mass spectrometry-based biomarkers, especially targeted panels of protein biomarkers, thereby supporting both the diagnosis and therapeutic management of neurodegenerative diseases. Biomarkers are of paramount importance in clinical trials, providing essential insights into patient stratification, therapeutic efficacy, safety profiles, and elucidation of mechanisms of action.

Key Responsibilities

• Development and validation of novel mass spectrometry-based assays for early- and late-phase clinical trials in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, ALS, and rare brain disorders.

• Work with project team leads, including Vice President of Neuroscience Biomarker Development and Executive Director for mass spectrometry-based biomarker discovery, and other associates to perform experiments to support both the preclinical and clinical characterization and evaluation of therapeutic molecules through biomarker assay development.

• Work directly on-site in the laboratory with method development, optimization, and sample analyses, and with summarizing and reporting method status of results for internal partners.

• Design and execute assay qualification and validation studies appropriate to the intended context of use, including assessment of precision, accuracy, selectivity, stability, parallelism, and matrix effects.

• Collaborate cross-functionally with internal stakeholders (medical, operations, statistics, regulatory) and external partners (CROs, academic institutions) to ensure biomarker validation and successful integration into clinical programs.

Basic Qualifications

• PhD in analytical chemistry, biochemistry, neuroscience, proteomics, or a related field, with 3-5 years of academic, or industry experience in LC-MS method development for biomarker applications.

Additional Skills / Preferences

• All levels: Hands-on experience with high-resolution and/or triple quadrupole (QqQ) LC-MS for targeted (PRM/MRM) or DIA quantification of proteins or peptides in biofluids such as CSF or plasma, including the use of stable isotope labeled standards.

• Strong analytical skills and thorough knowledge of LC-MS method development, qualification, and validation procedures for biomarker assays.

• Prior experience supporting neuroscience or neurodegeneration biomarker programs is preferred.

• Experience with immunoprecipitation (IP-MS) is preferred.

• Proficiency with proteomics data analysis tools (e.g., Spectronaut, Skyline, R, Python).

• Excellent communication and collaboration skills, with the ability to present  to influence both internal and external stakeholders.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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