Bioinformatics Engineer (Hybrid)

Pay Range: $95,000.00 - $125,000.00 / year

Salary offers are based on a wide range of factors including relevant skills, training, experience, education, and, where applicable, certifications obtained. Market and organizational factors are also considered. Successful candidates may be eligible to receive annual performance bonus compensation.

Benefits Information

We are proud to offer best-in-class benefits and programs to support employees and their families in living healthy, happy lives. Our pay and benefit plans have been designed to promote employee health in all respects – physical, financial, and developmental. Depending on whether it is a part-time or full-time position, some of the benefits offered may include:

· Day 1 Medical, supplemental health, dental & vision for FT employees who work 30+ hours

· Best-in-class well-being programs

· Annual, no-cost health assessment program Blueprint for Wellness®

· healthyMINDS mental health program

· Vacation and Health/Flex Time

· 6 Holidays plus 1 "MyDay" off

· FinFit financial coaching and services

· 401(k) pre-tax and/or Roth IRA with company match up to 5% after 12 months of service

· Employee stock purchase plan

· Life and disability insurance, plus buy-up option

· Flexible Spending Accounts

· Annual incentive plans

· Matching gifts program

· Education assistance through MyQuest for Education

· Career advancement opportunities

· and so much more!

About Haystack Oncology

Haystack Oncology, now part of Quest Diagnostics, is a next-generation liquid biopsy company focused on advancing tumor-informed minimal residual disease (MRD) testing. Our proprietary technology enables highly sensitive and specific detection of circulating tumor DNA (ctDNA), improving patient outcomes through earlier detection of residual disease.

As we continue to expand our assay portfolio and bring cutting-edge diagnostics to the public, we are seeking a skilled Bioinformatics Scientist to join our growing team. This role will play a critical part in supporting clinical production testing, clinical trials, and assay R&D for Quest Diagnostics laboratories in the US and Europe.

Role Overview

As a Bioinformatics Scientist, you will develop and maintain cloud-based computational infrastructure for the analysis of genomic data from our proprietary MRD assays. You will work cross-functionally with laboratory, LIMS, and IT teams to ensure seamless integration of bioinformatics workflows with clinical and research operations.

• Develop & maintain cloud infrastructure for scalable and efficient genomic data analysis.

• Implement and optimize Python and Nextflow bioinformatics workflows.

• Integrate bioinformatics pipelines with Laboratory Information Management Systems (LIMS) to streamline data processing.

• Ensure compliance with IT security and privacy controls, aligning with Quest Diagnostics’ corporate policies.

• Apply software engineering best practices, contributing to the scalability, robustness, and maintainability of bioinformatics pipelines.

• Develop and manage databases and applications for quality control (QC) and assay performance monitoring.

• Document and validate bioinformatics systems in compliance with regulatory and quality standards for clinical diagnostics

Required

• Background in software or infrastructure engineering, with experience in bioinformatics.

• Proficiency in bioinformatics pipeline workflow management, particularly Nextflow (preferred), Cromwell, or CWL.

• Hands-on experience developing cloud-native infrastructure (AWS preferred) for storage, batch computing, and serverless applications.

• Expertise in infrastructure as code (IaC) technologies such as Terraform or AWS CDK.

• Strong programming skills in Python, JavaScript/TypeScript, R, or other relevant scripting languages.

• Experience with API development and integration, particularly JSON-based RESTful APIs.

• Deep understanding of version control (Git), CI/CD best practices, and software development lifecycle (SDLC).

• Ability to work cross-functionally in a multi-disciplinary environment with minimal supervision.

• Strong problem-solving, analytical, and troubleshooting skills, with the ability to diagnose and resolve technical issues.

• Excellent verbal and written communication skills in English, with the ability to translate technical concepts for non-technical stakeholders.

Preferred

• Experience in a clinical diagnostics or regulated environment (e.g., CLIA, CAP, IVDR, FDA) with knowledge of software validation and regulatory requirements.

• Understanding of controlled processes, environment management, and quality control systems in a clinical setting.

• Familiarity with DevOps methodologies.

Education

• Bachelor's Degree (Required)

• Master's Degree (Preferred